Intensive and semi-intensive aqua farming accompanies several disease problems often due to opportunistic pathogens as evident from general aquaculture. High stocking densities, high food inputs and other organic loads stimulate the selection and proliferation of opportunistic pathogens. The digestive system of shrimp is the main entry port for protozoan, bacterial and viral infections, which remain a major risk for the profitability of shrimp production. Accompanying acute hepatopancreatic necrosis disease (AHPND) in cultivated shrimps has been an increasing prevalence of vermiform, gregarine-like bodies within the shrimp hepatopancreas (HP) and midgut due to vibriosis, and parasitemia with the microsporidian Enterocytozoon hepatopenaei (EHP). In high quantity of these bodies result in white fecal strings and a phenomenon called white feces syndrome (WFS).The vermiform bodies formations are consisting of Aggregated Transformed Microvilli (ATM). The ATM have originated by sloughing from epithelial cells of the shrimp hepatopancreatic tubules. They accumulate at the HP-midgut junction before being discharged within feces via the midgut.
VIBTHERA is unique formulation for controlling white fecal disease. Formulation has been designed for controlling vibriosis and EHP infections along with immunostimulants to recover from infectious state of animals. Unique agglutinating IgY antibodies has also been used to remove vibrio infections from shrimp gut. Active principle from Phytochemicals and silver nanoparticle has been designed to control biofilm formation, toxin production via breaking quorum sensing communication among pathogens and removal of vibrio infections form shrimp gut. Phytochemicals and other active constituents have been delivered using nano-emulsion technology. Synergistic mechanism of formulation to control white fecal syndrome has been proven in several field trials from various locations of south India.