Intestinos Probiotics and Prebiotics

INTESTINOS^PP optimizes gut health for maximizing poultry performance, and a multifaceted approach involving lipid-encapsulated probiotics, prebiotics, tannins, polyphenols and Nanobutyrin offers significant benefits. Lipid encapsulation ensures probiotics like Lactobacillus, Clostridium, Bifidobacterium and Bacillus species reach the intestines intact, where they modulate gut motility with antispasmodic effects and inhibit pathogens through selective antibacterial activity. Tannins and polyphenols complement this by forming protective layers on the intestinal mucosa, reducing excessive secretion and hypermotility while suppressing harmful bacteria. Meanwhile, Nanobutyrin, an organic acid nanoparticle, promotes intestinal villi growth at the molecular level, enhancing nutrient absorption and strengthening gut barriers. Together, these strategies create a synergistic effect—balancing gut microbiota, improving nutrient uptake, and reducing disease risks without relying on antibiotics. This integrated approach not only supports better feed efficiency and growth performance but also aligns with sustainable and antibiotic-free poultry production practices.

Optimal gut health is crucial for enhancing growth performance, immunity, and overall productivity. Incorporating probiotics and prebiotics into feed offers a promising strategy to achieve these goals. The efficacy of probiotics in poultry feed depends significantly on their survival through the harsh gastric environment and their ability to reach the intestines intact. Lipid encapsulation has emerged as an innovative technique to protect probiotic bacteria such as Bifidobacterium bifidum, Clostridium butyricum, Lactobacillus acidophilus, Pedicoccus pentosaceus, Bacillus subtilis, Bacillus coagulans, Saccharomyces cerevisiae, Lactobacillus delbrueckii, Saccharomyces boulardii, and Lactobacillus rhamnosus during gastrointestinal transit. This method involves coating probiotics with lipid-based matrices, creating a protective barrier against gastric acids and bile salts, thereby enhancing their viability and controlled release in the intestines.

Once in the intestines, these encapsulated probiotics exert a range of beneficial effects. They produce bioactive compounds, including short-chain fatty acids (SCFAs) such as butyrate, which have antispasmodic properties that modulate gut motility. By soothing the smooth muscles of the intestinal wall, these compounds help prevent spasms and irregular peristalsis, ensuring a steady and efficient movement of digesta. This modulation of gut motility not only improves nutrient absorption but also minimizes the risk of disorders such as diarrhea.

Additionally, these probiotics exhibit selective antibacterial activity against pathogenic bacteria like Salmonella, Escherichia coli, and Clostridium perfringens. They produce antimicrobial peptides, organic acids, and bacteriocins that inhibit the growth of harmful microbes without affecting beneficial gut flora. Moreover, species such as Saccharomyces boulardii and Lactobacillus rhamnosus demonstrate antiviral effects by enhancing mucosal immunity and secreting bioactive peptides capable of neutralizing viral toxins.

The combination of lipid encapsulation and the synergistic action of diverse probiotic species thus ensures targeted delivery, enhanced stability, and a broad spectrum of benefits, including improved gut motility, selective pathogen inhibition, and enhanced immune responses. This strategy represents a promising approach for promoting gut health and productivity in poultry without relying on antibiotics.

Tannins and polyphenols, naturally occurring compounds in various plant sources, play a significant role in maintaining gut health by forming protective complexes with proteins in the intestinal mucosa. When ingested, these bioactive compounds bind to mucosal proteins, creating a protective layer that shields the gut lining from irritants and pathogens. This protective barrier reduces excessive secretion of fluids into the intestinal lumen, a common cause of diarrhea, and prevents hypermotility by calming the smooth muscle contractions in the gut. As a result, intestinal transit time is regulated, allowing for better nutrient absorption and more stable gut function.

Additionally, tannins and polyphenols possess potent antimicrobial properties that inhibit the growth of harmful bacteria such as Escherichia coli, Salmonella, and Clostridium perfringens. They achieve this by disrupting bacterial cell walls and inhibiting essential enzymes required for microbial survival. By selectively suppressing pathogenic bacteria while sparing beneficial gut microbiota, these compounds help maintain a balanced microbial environment.

The combined effects of forming a protective mucosal layer and exerting selective antimicrobial activity make tannins and polyphenols valuable in preventing gastrointestinal disturbances and enhancing overall gut health. Their use in poultry feed can contribute to improved digestion, reduced incidence of enteric diseases, and enhanced growth performance.

Nanobutyrin, an advanced form of butyric acid encapsulated in carbon quantum dots based organic nanoparticles, significantly promotes intestinal villi growth at the molecular level in poultry. Its nano-sized particles enhance bioavailability and targeted delivery to the intestines, ensuring prolonged release and absorption. Butyric acid acts as an energy source for enterocytes, stimulating gene expression related to cell proliferation and differentiation. This leads to increased villus height and surface area, enhancing nutrient absorption and gut health. Additionally, Nanobutyrin strengthens tight junctions between cells, reducing gut permeability and preventing pathogen entry, ultimately improving feed efficiency, immunity, and overall performance in poultry birds.