Preevee EHP Management

The hepatopancreatic microsporidian Enterocytozoon hepatopenaei (EHP) is an emerging pathogen that affects cultured shrimp Penaeus vannamei. The microsporidium EHP, is probably the most important disease in shrimp farming at the moment. The main clinical signs of EHP are growth retardation, which leads to increased size variability. In advanced stages of the disease, EHP-infected shrimp typically display soft shells, and chronic mortalities. In some cases, the coinfection of EHP and Vibrio spp. has been associated with the development of white faeces syndrome (WFS). Histopathological lesions induced by EHP in the hepatopancreas display irregular/regular basophilic inclusion bodies within the cytoplasm, with or without the presence of spores. Acute Hepatopancreas Necrosis Disease (AHPND) also known as Early Mortality Syndrome (EMS) began causing significant, farmed shrimp mortalities and production losses. The strong association found between cases of septic hepatopancreatic necrosis (SHPN) and EHP suggests that EHP increases shrimp susceptibility to infection by Vibrio bacteria – known opportunistic pathogens that cause disease when shrimp health is compromised. EHP infection disrupts the cells of the hepatopancreas tubules and allows Vibrio spp. Controlling Enterocytozoon hepatopenaei (EHP), a microsporidian parasite affecting shrimp, is challenging due to its resilience and persistence in shrimp farms. Natural compounds like essential oils and plant-based bioactives are being explored for their potential antimicrobial, anti-parasitic, and immune-boosting effects. Compounds like cinnamaldehyde, citral A, thymol, carvacrol, tea tree oil, menthol, camphor, oleuropein, liquorice, eucalyptus oil, and curcumin exhibit various antimicrobial and anti-parasitic properties that may help in managing EHP infections. By combining them in carefully managed doses, shrimp farms can enhance resilience against EHP while promoting sustainable and eco-friendly practices in aquaculture.

Our innovative formulation comprising of silver nanoparticle, Copper Nanoparticle, Selenium Nanoparticle and Chromium Nanoparticles and unique herbal purified active compounds cocktails helped to control further multiplication of EHP and regain the growth of hepatopancreas as well as shrimp. This feed additive helps to control size variation of shrimp and excel growth back to normal. Approach to control using plant essential oils and nanotechnology to control EHP and related symptoms have provided new look of disease control. Associated symptoms of the disease can also be improved with different fatty acids, phospholipids, chelated minerals and antioxidants. This helps to control viral, bacterial and associated other infectious agents and help to improve productivity. In addition, chelated minerals, vitamins and growth promotors helps to improve recovery from disease.